Pliva 433

Also known as Trazodone hydrochloride 50 mg, it is used for the treatment of insomnia; anxiety; sedation; fibromyalgia; major depressive disorder (and more), and belongs to the drug class phenylpiperazine antidepressants.

It is usually prescribed to treat depression and belongs to a group of drugs called serotonin modulators, which affect the natural substance, serotonin, in the brain.

This medication comes in tablet form and is taken up to 4 times a day after a meal or snack or as an extended release tablet, taken once a day in the late evening, preferably at bedtime, on an empty stomach.

Trazodone Precautions

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

This also should not be taken if you are allergic to it, or if you are being treated with methylene blue injection. Inform the doctor of any medications you take, including over-the-counter medicines, herbal remedies, vitamins, and supplements.

Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. Immediately call the healthcare provider for new or sudden changes in mood, behavior, thoughts, or feelings, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Trazodone is not approved for use in children.

During pregnancy, antidepressants may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant while taking trazodone. Do not start or stop taking this medicine during pregnancy without your doctor’s advice. Also, inform the doctor if you are breast-feeding a baby since it is not known whether trazodone passes into breastmilk or if it could harm a nursing baby.

Side Effects

To make sure trazodone is safe for you, tell your doctor if you have:

  • liver or kidney disease;
  • heart disease;
  • a bleeding or blood clotting disorder;
  • seizures or epilepsy;
  • narrow-angle glaucoma;
  • bipolar disorder (manic depression);
  • a history of Long QT syndrome;
  • a history of drug abuse or suicidal thoughts; or
  • if you have recently had a heart attack.

 Avoid alcohol and driving until you know how trazodone will affect you. Common side effects include drowsiness, dizziness, and dry mouth.

Serious side effects include:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling very agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worrying you.


This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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