IP 203 (Acetaminophen and oxycodone hydrochloride 325 mg / 5 mg)

Oxycodone is an opioid (narcotics) pain medication, while acetaminophen (also known as paracetamol) is a less potent pain reliever that increases the effects of oxycodone. A combination of both relieves moderate to severe pain.

Oxycodone Hydrochloride and Acetaminophen Tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. This pill belongs to the drug class narcotic analgesic combinations and is white, round, with an imprint “IP 203.”

Narcotic Analgesics are a group of medicines that relieve acute and chronic severe pain by binding to opioid receptors.  These influence the opioid system which controls pain, reward and addictive behaviors. As an opioid, Oxycodone Hydrochloride and Acetaminophen Tablets expose users to the risks of addiction, abuse, and misuse.


 Common side effects include:

  • headache, drowsiness, tiredness;
  • nausea, vomiting, stomach pain, constipation;
  • blurred vision; or
  • dry mouth.

 Serious Side Effects

  • shallow breathing, slow heartbeat;
  • a light-headed feeling, like you might pass out;
  • confusion, unusual thoughts or behavior;
  • seizure (convulsions);
  • problems with urination;
  • infertility, missed menstrual periods;
  • impotence, sexual problems, loss of interest in sex;
  • liver problems–nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low cortisol levels–nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Signs of an allergic reaction

  • hives;
  • difficulty breathing;
  • swelling of your face,
  • lips, tongue, or throat

In rare occasions, acetaminophen causes a severe skin reaction such as skin redness or a rash that spreads and causes blistering and peeling. Immediately call the doctor as these signs are  fatal. Seek emergency help with allergic reaction and serious side effects of this drug. Some symptoms not listed above may be experienced. Report to your doctor any symptom that becomes unusual or bothersome.


  • The use of oxycodone hydrochloride and acetaminophen tablets can result to addiction, misuse, and overdose which can lead to fatal side effects or death.
  • Patients are at risk of respiratory depression when starting the medication or when dosage is increased. Seek medical attention in case of difficulty in breathing.
  • There is a risk of accidental Ingestion especially in children. Store and dispose the tablets properly. In case of accidental ingestion, immediately seek emergency help.
  • This medicine interacts with benzodiazepines and other CNS depressants, including alcohol, and other medicines with similar content. Use with caution and follow doctor’s instructions.
  • Oxycodone Hydrochloride and Acetaminophen Tablets can interact with other medications. Tell the physician your medical history including medications taken (over-the-counter, vitamins, herbal medicines, etc.) and before you take any new medicines or if you plan to undergo surgery.


  • Consult your physician on proper drug dosage and administration. Do not suddenly stop taking the medication or increase/decrease your dosage without doctor’s advice.
  • Do not double dose in case of a missed dose. Skip the schedule if it is almost time to take the next dose.
  • In case of an overdose, seek emergency help. Symptoms include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.
  • This medicine causes dizziness and drowsiness. Carefully rise from a sitting or lying position. Do not drive or operate machineries while taking this medicine or do activities that require you to be awake, alert, or to think. This drug also impairs thinking and reactions.
  • Acetaminophen and oxycodone hydrochloride is harmful to the unborn child and nursing infant. Inform the doctor if you are pregnant, planning to get pregnant, or breastfeeding.
  • This drug causes constipation. Increase daily water intake from 6 to 8 full glasses of water and increase fiber in diet. Avoid use of stool softeners without doctor’s advice.
  • An extended-release pill should be swallowed whole to avoid exposure to potentially fatal dose. Liquid form of this drug should be measured properly.
  • Store at room temperature away from moisture and heat.



This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.


Leave a Reply

Your email address will not be published. Required fields are marked *